Change and significance of serum levels of homocysteine, uric acid and blood lipid in patients with chronic heart failure

REN Lu; GUO Liang

doi:10.3969/j.issn.1002-7386.2017.14.008

Abstract：Objective To observe the changes of serum levels of homocysteine ( Hcy ) , uric acid ( UA ) , total cholesterol ( TC ) , triglyceride ( TG ) , high density lipoprotein cholesterol ( HDL-C ) , low density lipoprotein cholesterol ( LDL-C) ,lipoprotein a [ Lp ( a) ] in patients with chronic heart failure,and to analyze the correlation between these indexes and cardiac function in order to evaluate the clinical significance of these indexes in diagnosis and treatment of chronic heart failure. Methods One hundred and ninety-two patients with chronic heart failure who were admitted and treated in our hospital from February 2013 to August 2016 were selected as observation group, moreover, these patients were divided into three subgroup according to the cardiac function classification by American Heart Association (NYHA),grade Ⅱ subgroup (n=46),grade Ⅲ subgroup (n=108) and grade IV subgroup (n=38), furthermore, the other 74 healthy subjects were served as control group. The serum levels of Hcy, UA,TC,TG,HDL-C,LDL-C,Lp ( a) were detected and compared between observation group,control group and subgroups. The correlation between serum levels of Hcy,UA,TC,TG,HDL-C,LDL-C,Lp ( a) and cardiac function classification was analyzed by Spearman rank correlation analysis. Results As compared with those in control group,the serum levels of Hcy,UA,Lp ( a) in observation group were significantly increased,however, the serum levels of TC,TG,HDL-C were significantly decreased (P<0. 05),but there were no significant differences in serum levels of LDL-C between the two groups (P>0. 05). There were significantly differences in serum levels of Hcy,UA,TC,TG,HDL-C, Lp (a) among gradeⅡgroup,gradeⅢgroup andⅣsubgroup (P<0. 05),but there were no significant differences in serum levels of LDL-C between any two subgroups (P>0. 05). Spearman rank correlation analysis showed that serum levels of Hcy, UA,Lp (a) were positively correlated with NYHA classification (P<0. 05),however,the serum levels of TC,TG,HDL-C were negatively correlated with NYHA classification (P<0. 05),moreover, there was no significant correlation between the serum levels of LDL-C and NYHA classification (P>0. 05). Conclusion The serum levels of Hcy,UA,TC,TG,HDL-C and Lp ( a) are changed with the deterioration of cardiac function in patients with chronic heart failure, which may be used as reference indexes for assessment of patient's condition of disease,moreover, the detection of serum levels of these indexes has important clinical significance in instructing early intervention to reduce the risk of long-term cardiovascular events.