Effects of small-dose phenylephrine on capacity of circulation in parturients receiving cesarean section with epidural anesthesia

REN Jianguang; WU Yajuan; WANG Wenjun

doi:10.3969/j.issn.1002-7386.2017.14.004

Abstract：Objective To investigate the effects of small-dose phenylephrine on of circulation capacity distribution in parturients receiving cesarean section with epidural anesthesia. Methods Sixty-three parturients who underwent cesarean section with epidural anesthesia were randomly divided into observation group ( n =32 ) and control group ( n =31 ) . The parturients in control group were given colloidal fluid to keep circulation capacity during operation,however, the parturients in observation group were given colloidal fluid +phenylephrine during operation. The changes of blood pressure and heart rate, blood volume, plasma volume, hemoglobin, red cell volume were observed and compared between two groups on admiting into operation room, at 10min after administration,on openning womb,during fetus being taken out,at 10min after fetus was taken out,at the end of operation. And the adverse reactions during operation were observed for both groups. Results The mean arterial pressure in observation group was decreased from 10min after administration to the end of surgery,as compared with that on admiting into operation room,however,the difference was not statistically significant ( P >0. 05),but which in control group on admiting into operation room was significantly decerased, as compared with that on openning womb,during fetus being taken out,at 10min after fetus was taken out ( P <0. 05). There were no significant differences in the changes of heart rate in different time points in observation group ( P >0. 05),however, the heart rate in control group on openning womb and during fetus being taken out was significantly increased ( P <0. 05). There werer no significant differences in blood volume,plasma volume, hemoglobin, red cell volume from 10min after administration to the end of surgery in observation group,as compared with those on admiting into operation room ( P >0. 05),however, the blood volume and plasma volume on openning womb, during fetus being taken out,at 10min after fetus was taken out in control group were significantly increased,as compared with those on admiting into operation room ( P <0. 05),but hemoglobin and red cell volume were significantly decreased ( P <0. 05). The incidence rate of adverse reactions was 9. 38% in observation group, which was 16. 13% in control group, there was no significant difference between two groups (χ2 =0. 5023, P >0. 05). Conclusion The small-dose phenylephrine can keep heart rate and stabilize blood pressure in parturients receiving cesarean section with epidural anesthesia, which can decrease excessive fluid expansion due to hemodilution by colloid, with safety and few adverse side effects, thus, which is suitable for clinical application.