Effects of pemetrexed,paclitaxelliposome and best supportive therapy on immune function and inflammatory cytokines of advanced pulmonary adenocarcinoma patients with performance status of 2
Abstract：Objective To observe the effects of pemetrexed,paclitaxelliposome and best supportive therapy on immune function and inflammatory cytokines of advanced pulmonary adenocarcinoma patients with performance status of 2.Methods A total of 101 patients with advanced pulmonary adenocarcinoma who were admitted and treated in our hospital from January 2014 to October 2016 were randomly divided into three groups:pemetrexed group (PEM group,n =34),paclitaxelliposome (LEP group,n=33) and best supportive therapy group (BSC group,n =34),with a treatment course of 21 days for 2 courses of treatment.The aggravation rate of PS scoring and the changes of CD3+,CD4+,CD8+,CD4+ /CD8+,CD4+CD2+5,CD1+65+6 T,IFN-γ,TNF-α,NK,NKG2D,CEA and CA125 were observed and compared among the three groups.Results The aggravation rate of PS scoring in PEM group and LEP group was 26.47%,27.27%,respectively,which was significantly lower than that (67.65%) in BSC group (P<0.05).As compared with those before treatment,the levels of CD3+,CD4+,CD4+ /CD8+,CD1+65+6 T,IFN-γ,NK and NKG2D in PEG group and LEP group were significantly increased after treatment,but the levels of CD8+,CD4+CD2+5 T,TNF-α,CEA and CA125 were significantly decreased in the two groups (P<0.05).However there were no significant differences in these indexes mentioned above in BSC group before treatment and after treatment (P>0.05).Conclusion The single pemetrexed or single paclitaxelliposome is superior to best supportive therapy in enhancing immune function of advanced pulmonary adenocarcinoma patients with performance status of 2,which can inhibit inflammatory reaction so as to postpone the progression of disease.
Keywords：pemetrexedpaclitaxelliposomebest supportive therapyadvanced pulmonary adenocarcinomaimmune functioninflammatory cytokines
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1944-1947 )