The anesthesia effects of different doses of oxycodone combined with propofol in patients underwenting hysteroscopy

WANG Mingyu; ZHU Shanshan

doi:10.3969/j.issn.1002-7386.2017.13.004

Abstract：Objective To observe the anesthesia effects of different doses of oxycodone combined with propofol in patients underwenting hysteroscopy.Methods One hundred and twenty patients who would receive hysteroscopy were randomly divided into four groups,with 30 patients in each group.The patients in group P were treated by 2mg/kg propofol,the patients in group Q1 were treated by propofol with oxycodone 0.06mg/kg,the patients in group Q2 were treated by propofol with oxycodone 0.09mg/kg and the patients in group Q3 were treated by propofol with oxycodone 0.12mg/kg .The patients in group Q1,group Q2,group Q3 and group P were given oxycodone 0.06,0.09,0.12mg and same volume 0.9% sodium chloride solution,respectively by slow intravenous injection before operation.The preoperative drugs were diluted to 10ml,and injection time was more than 1min.On 3min after injection of the drugs,propofol 2mg was injected intravenously.The mean arterial pressure (MAP) and heart rate (HR) were recorded,respectively,at the time of unconsciousness,cervix relaxation and in different time points after hysteroscopy.The consumption of propofol,the incidence rate of respiratory depression,consciousness recovery time after operation and adverse reactions were observed,moreover,the Prince-Henry scores were evaluated at the time of 0 min (T1),15min (T1),30min (T2) and 60min (T3) after revival.Results As compared with MAP in basic state,the MAP [(65.2 ±9.5)mm Hg] in unconsciousness in group P was significantly decaresed (P<0.05),however the MAP [(88.4 ±11.3)mm Hg] in cervix relaxation was significantly increased in group P and group Q1 (P<0.05).The consumption of propofol [(180 ±12)mg] in group P was significantly higher than that in group Q2 [(149 ±12)mg] and group Q3 [(146 ±11)mg] (P<0.05),but the consumption of propofol in group Q2 and group Q3 during operation was significantly lower than that in group P (P<0.05),moreover,the incidence rate of respiratory depression in group Q2 and group Q3 was significantly lower than that in group P (P<0.05).As compared with those in group P,the Prince-Henry scores (>2 points) in group Q1,group Q2,group Q3 were significantly decreased (P<0.05 or P<0.01),The incidence rate of dysphoria in group P (13.3%) was significantly higher than that in group Q2 (3.3%) and group Q3 (3.3%) (P<0.05).However the incidence rate of headache in group Q3 after operation was significantly higher than that in group P group,group Q1 and group Q2 (P<0.05).Conclusion The different doses of oxycodone combined with propofol in hysteroscopy surgery can decrease dosage of propofol,reduce the incidence rate of respiratory depression,improve patient' s pain score.Moreover oxycodone combined with propofol at dose of 0.09mg/kg has better clinical application value.