Clinical significance of serum PON-1,Salusin-α and Omentin-1 in elderly patients with acute cerebral infarction

QIAO Yehong; CHEN Yan; WANG Jing'e

doi:10.3969/j.issn.1002-7386.2017.12.008

Abstract：Objective To investigate the clinical significance of serum paraoxonase-1 (PON-1),Salusin-α and Omentin-1 in elderly patients with acute cerebral infarction (ACI).Methods Seventy-five elderly patients with ACI who were treated in our hospital from January 2014 to June 2016 were enrolled as ACI group, at the same time, the other 30 healthy subjects were served as control group.The serum levels of PON-1,Salusin-α and Omentin-1 were detected by enzyme-linked immunosorbent assay (ELISA).The correlation betweeen the levels of PON-1,Salusin-α , Omentin-1 and carotid plaque character,infarction area, neurologic impairment was analyzed,moreover, the correlation among these indexes was also analyzed.Results The serum levels of PON-1,Salusin-α and Omentin-1 in ACI group were significantly lower than those in control group (P<0.01).The levels of PON-1,Salusin-α and Omentin-1 in ACI group were decreased with the increase of unstable degree of carotid artery plaque,cerebral infarction area and neurologic impairment severity (P<0.01).The levels of serum PON-1 in ACI group were positively correlated to those of Salusin-α (r=0.572,P<0.05) and Omentin-1 (r=0.487,P<0.05), moreover, the levels of Salusin-α were also positively correlated to those of Omentin-1 (r=0.752,P<0.05).Conclusion The PON-1,Salusin-α and Omentin-1 are involved in the pathogenesis and development of acute cerebral infarction in elderly patients,and these indexes are important protective factors for patients with ACI,thus,the early monitoring of these indexes is helpful to evaluate pathogenetic condition and prognosis of patients.