Correlation between serum levels of Hcy,lipid and carotid atherosclerosis in patients with type 2 diabetes mellitus complicated by hypertension
SU Chengdan
Abstract：Objective To investigate the dynamic changes of serum levels of Hcy and lipid levels in patients with type 2 diabetes mellitus (T2DM) complicated by hypertension,and to analyze the correlation between serum levels of Hcy,lipid and carotid atherosclerosis.Methods The patients with T2DM were divided into T2DM group (n=60) and HBP+T2DM group (n=60) according to whether they had hypertension,at the same time,60 healthy olderly subjects were served as control group.The detection indexes included fasting blood glucose (FPG),blood lipids (TC,TG,HDL-C and LDL-C),Lpa,ApoA-Ⅰ,ApoB,Hcy and IMT,plaque Crouse integral,the detection rate of plaques, in which, FPG was determined by glucose oxidase method,the levels of TC,TG,HDL-C and LDL-C were detected by double enzymatic reagent method,the levels of Lpa,ApoA-Ⅰand ApoB were detected by double reagent immunoturbidimetry,and Hcy levels were detected by double reagent circulating enzyme method.Results The levels of TC,TG,LDL-C,Lpa, ApoB, IMT, plaque Crouse integral and the detection rate of plaques were increased in order of control group,T2DM group and T2DM group,moreover, there were significant differences between every two groups (P<0.05).The FPG levels in T2DM group and T2DM+HBP group were significantly higher than those in control group (P<0.05),however, there were no significant differences between T2DM group and T2DM+HBP group (P>0.05).As compared with those in control group, the levels of HDL-C and ApoA-Ⅰin T2DM group and T2DM+HBP group were significantly decreased (P<0.05), however, there were no significant differences between T2DM group and T2DM+HBP group (P>0.05).The levels of IMT were positively correlated to those of FPG, TC, TG,LDL-C,Lpa,ApoB and Hcy (r=2.332,3.412, 3.571,3.274, 3.841,3.466, 4.872, respectively,P<0.05),however,which were negatively correlated to those of HDL-C and ApoA-Ⅰ (r=-0.561,-0.759,respectively,P<0.05).Conclusion The patients with type 2 diabetes mellitus complicated by hypertension have higher risk of carotid atherosclerosis, moreover, fasting blood glucose,lipid and serum Hcy levels are closely correlated to carotid atherosclerosis,thus, monitoring serum Hcy and IMT levels and early intervention have a certain clinical value to decrease the occurrence and development of carotid atherosclerosis.
Keywords：T2DM with hypertensionHcylipidcarotid artery atherosclerosis
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1788-1791,1795 )