Clinical significance of detection of Obestatin,Gal-3 and AGEs in patients with type Ⅱcardiorenal syndrome

HUANG Wenwen

doi:10.3969/j.issn.1002-7386.2017.12.002

Abstract：Objective To investigate the clinical significance of Obestatin,Galectin-3 (Gal-3) and advanced glycation end products (AGEs) in pathogenesis and development of type II cardiorenal syndrome.Methods Ninety-five patients with chronic heart failure who were treated in our hospital from January 2014 to June 2016 were divided into simple heart failure group (n=30) and cardiorenal syndrome group (n=65) according to the levels of glomerular filtration rate (eGFR),moreover, the other 20 healthy subjects were served as control group.The levels of Obestatin,Gal-3 and AGEs were detected in the three groups, furthermore, the correlation between the levels of Obestatin,Gal-3, AGEs and heart function,renal function were analyzed,besides, the correlation among the indexes was also analyzed.Results The levels of Obestatin,Gal-3 and AGEs in cardiorenal syndrome group were significantly higher than those in simple heart failure group and control group (P<0.01),moreover, which in simple heart failure group were significantly higher than those in control group (P<0.01).The levels of Obestatin,Gal-3 and AGEs in cardiorenal syndrome group were increased with the increase of cardiac function and renal function (P<0.01).The levels of Obestatin in cardiorenal syndrome group were positively correlated to those of Gal-3 (r=0.572,P<0.05) and those of AGEs (r=0.726,P<0.05).The levels of Gal-3 were positively correlated to those of AGEs (r=0.587,P<0.05).Conclusion The Obestatin,Gal-3 and AGEs are involved in the pathogenesis and development of type II cardiorenal syndrome.The combined detection is helpful to the early diagnosis of the disease,moreover,which has important clinical significance in evaluating severity of the disease.