Therapeutic effects of transfer factor on the basis of antibiotics sequential therapy in treatment of acute lower respiratory tract infection in children

CHEN Ling; QIN Jun; HU Jingjiang

doi:10.3969/j.issn.1002-7386.2017.11.007

Abstract：Objective To observe the therapeutic effects, the improving time of clinical symptoms and laboratory indexes of transfer factor on the basis of antibiotics sequential therapy in treatment of acute lower respiratory tract infection in children.Methods Eighty children patients with acute lower respiratory tract infection who were admitted and treated in our hospital from February 2014 to October 2014 were randomly divided into control group and observation group ,with 40 patients in each group.The patients in both groups underwent routine examination and treatment,and the patients in control group were treated by antibiotic sequential therapy,however,the patients in observation group,on the basis of control group,were treated by transfer factor oral liquid.Then the therapeutic effects,improving time of clinical symptoms,length of staying in hospital,laboratory indexes and incidence rate of adverse reactions were observed and compared between two groups.Results After treatment,the pyretolysis time,cough relief time and length of staying in hospital in observation group were significantly shorter than those in control group (P<0.05).After treatment the cellular immunity function,levels of CRP,PCT and WBC were significvantly changed in both groups,as compared with those before treatment,moreover,the changes in observation group were more obvious than those in control group (P<0.05).Besides,the total effective rate was 95.0% in observation group,and incidence rate of adverse reactions was 27.5%,which were suprior to those in control group (P<0.05).Conclusion The transfer factor on the basis of antibiotics sequential therapy in treatment of acute lower respiratory tract infection in children can obviously shorten the improving time of clinical symptoms and length of staying in hospital, reduce the incidence rate of adverse reactions,improve efficiency,with good therapeutic effects, thus, which is worth using widely in clinical practice.