Significance of 3-NT,HIF-1α and 8-iso-PGF-2α in OSAHS patients with hypertension

LI Ying; WANG Xiufang

doi:10.3969/j.issn.1002-7386.2017.11.004

Abstract：Objective To investigate the significance of 3-nitro-tyrosine (3-NT),hypoxia-inducible factor-1α (HIF-1α) and 8-isoprostane (8-iso-PGF-2α) in obstructive sleep apnea hypopnea syndrome (OSAHS) patients with hypertension.Methods One hundred and forty-nine patients with OSAHS who were treated in our hospital from January 2010 to December 2015 were divided into simple OSAHS group (n=43) and OSAHS with hypertension group (n=106) according to whether OSAHS combined with hypertension.At the same time,35 healthy subjects were served as control group.The serum levels of 3-NT ,HIF-1α and 8-iso-PGF-2α were detected,and the correlation between the levels of 3-NT ,HIF-1α , 8-iso-PGF-2α and apnea-hypopnea index (AHI) in OSAHS patients with hypertension was analyzed,moreover after treatment,the changes of the levels of these factors were observed,besides, the correlation among these factors was analyzed.Results The serum levels of 3-NT,HIF-1α and 8-iso-PGF-2α in simple OSAHS group and OSAHS with hypertension group were significantly higher than those in control group (P<0.01),moreover,which in OSAHS with hypertension group were significantly higher than those in simple OSAHS group (P<0.01).The levels of 3-NT,HIF-1α and 8-iso-PGF-2αin OSAHS with hypertension group were increased with the increase of AHI (P<0.01),after treatment,the levels of 3-NT,HIF-1α and 8-iso-PGF-2α were significantly decreased,as compared with those before treatment (P<0.01).The levels of 3-NT were positively correlated to those of HIF-1α (r=0.594,P<0.05) and 8-iso-PGF-2α(r=0.647,P<0.05),moreover, the levels of HIF-1αwere positively correlated to those of 8-iso-PGF-2α (r=0.781,P<0.05).Conclusion The 3-NT,HIF-1α and 8-iso-PGF-2α are involved in the pathogenesis and development of OSAHS,which can be regarded as important predictors in patients with OSAHS complicated by hypertension.