The change of serum bone metabolism related cytokines in patients with Graves ophthalmopathy and its correlation with bone mineral density

doi:10.3969/j.issn.1002-7386.2017.11.002

Abstract：Objective To investigate the change of serum bone metabolism related cytokines in patients with Graves ophthalmopathy (GO) and its correlation with bone mineral density.Methods Sixty patients with GO who were admitted and treated in our hospital from May 2014 to October 2016 were enrolled as GO group,who were redivided into two subgroups:mild GO group (n=18) and severe GO group (n=42),meanwhile, 40 healthy subjects were served as control group.The serum bone metabolism related cytokines including osteoprotegerin (OPG),nuclear factor-κ beta receptor activator ligand (RANKL), interleukin-6 (IL-6),interleukin-10 (IL-10),tumor necrosis factor α (TNF-α),insulin-like growth factor Ⅰ(IGF-Ⅰ) and bone mineral density (BMD) in lumbar vertebrae (L2~4),femoral neck,ward triangle and trochanter major were detected for the three groups.Results The serum levels of OPG,RANKL,IL-6 and TNF-α in GO group were significantly increased, however,the levels of OPG/RANKL,IL-10 and IGF-Ⅰwere obviously decreased, as compared with those in control group.Moreover the serum levels of OPG,RANKL,IL-6 and TNF-αin severe GO group were significantly higher than those in mild GO group,however, the levels of OPG/RANKL,IL-10 and IGF-Ⅰin severe GO group were significantly lower than those in mild GO group (P<0.05).The levels of BMD in lumbar 2~4 (L2~4),femoral neck,Ward's triangle and trochanter region in GO group were obviosuly decreased,as compared with those in control group,furthermore,which in severe GO group were significantly lower than those in mild GO group (P<0.05).The correlation analysis showed that the serm levels of OPG,RANKL,OPG/RANKL,IL-6,IL-10,TNF-α and IGF-Ⅰin control group were not correlated to the levels of BMD in different sites (P>0.05).However the levels of OPG,RANKL,IL-6 and TNF-α in GO group were negatively correlated with the levels of BMD in different sites (r=-0.685,-0.722,-0.775,-0.798,respectively,P<0.05),however, the levels of OPG/RANKL,IL-10 and IGF-Ⅰin GO group were positively correlated with the levels of BMD in different sites (r=0.712,0.689,0.803,respectively,P<0.05).Conclusion The serum levels of OPG,RANKL,IL-6 and TNF-α in patients with GO are increased,but the levels of OPG/RANKL,IL-10 and IGF-Ⅰare decreased,moreover,the changes are closely related with bone metabolism abnormality and BMD decrease.