Therapeutic effects and side effects of different doses of methylprednisone on severe asthma
Abstract：Objective To observe the therapeutic effects and side effects of different doses of methylprednisone on severe asthma.Methods Sixty-four patients with severe asthma who were treated in our hospital from May 2014 to May 2016 were randomly divided into control group,observation group A,observation group B,observation group C,with 16 patients in each group.The patients in control group were treated by dexamethasone (0.3~0.5mg·kg-1·d-1),however,the patients in observation group A,B,C were treated by methylprednisolone of 1~1.5mg·kg-1·d-1,2~4mg·kg-1·d-1,6~8mg·kg-1·d-1,respectively.The total effective rate,PaO2 and PaCO2,improvement time of symptoms and signs,toxic and side effects were observed and compared among the four groups.Results The total effective rate in observation group A,B,C was significantly higher than that in control group (P<0.05),which in observation group B and group C was significantly higher than that in group A (P<0.05).The PaO2 in observation group A,B,C was significantly higher than that in control group (P<0.05),however,the PaCO2 in the three groups was significantly lower than that in control group (P<0.05).The PaO2 in observation group B was significantly higher than that in group A (P<0.05),moreover,PaO2 in observation group C was significantly higher than that in group B (P<0.05).The improvement time of symptoms and signs in observation group A,B,C was significantly shorter than that in control group (P<0.05),and the improvement time in observation group B was significantly shorter than that in group A (P<0.05),moreover,which in group C was significantly shorter than that in group B (P<0.05).The incidence rate of upper gastrointestinal bleeding,the levels of blood glucose and blood pressure in observation group A,B,C were significantly higher than those in control group (P<0.05),moreover,the levels of blood glucose and blood pressure in observation group C were significantly higher than those in group A and group B (P<0.05).Conclusion The methylprednisolone at the dose of 3~4mg·kg-1·d-1 has satisfactory therapeutic effects on severe asthma,with few side effects,therefor,which is worth using widely in clinical practice.
Keywords：methylprednisoloneasthmacurative effectstoxic and side-effects
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1474-1476,1480 )