Effects of continuous blood purification combined with Dachengqi decoction on inflammatory factors,immunologic function and biochemical parameters in patients with severe acute pancreatitis
MA Li
HAN Baoyan
LU Mengxi
Abstract：Objective To investigate the effects of continuous blood purification combined with Dachengqi decoction on clinical symptoms,inflammatory factors,immunologic function and biochemical parameters in patients with severe acute pancreatitis.Methods One hundred and forty patients with severe acute pancreatitis were randomly divided into trial group and control group,with 70 patients in each group.The patients in control group were treated by continuous blood purification and conventional therapy,however,the patients in trial group,on the basis of control group,were given Dachengqi decoction (150 ml once,twice a day) by gavage.The disappearing time of abdominal pain and abdominal distension,the recovery time of borborygmus,evacuating and defecation,the length of staying in hospital were observed for both groups.Moreover the inflammatory factors including TNF-α,IL-1β,IL-6,IL-8,immunologic function and biochemical parameters including creatinine,diastase and procalcitonin before and after treatment were detected and compared between two groups.Besides the therapeutic effects were observed and compared between two groups.Results After treatment the disappearing time of abdominal pain and abdominal distension,the recovery time of borborygmus,evacuating and defecation,the length of staying in hospitalin in trial group were significantly shorter than those in control group (P<0.05).After 2-week treatment,the levels of TNF-α,IL-1β,IL-6,IL-8,creatinine,diastase and procalcitonin were obviously lower than those before treatment in both groups,moreover,which in trial group were significantly lower than those in control group (P<0.05).After treatment the levels of IgG,IgA,IgM,CD+3,CD+4,CD+8 in control group were significantly lower than those before treatment (P<0.05).However,the levels of IgG,IgA,IgM,CD+4 in trial group after treatment were significantly higher than those before treatment (P<0.05),moreover,the levels of CD+3,CD+8 were higher than those before treatment,but there were no significant differences (P>0.05).The levels of IgG,IgA,IgM,CD+3,CD+4,CD+8 in trial group were significantly higher than those in control group (P<0.05).Besides the cure rate,excellence rate and total effective rate in trial group were significantly higher than those in control group (P<0.05).Conclusion The continuous blood purification combined with Dachengqi decoction in treatment of severe acute pancreatitis can improve clinical symptoms,reduce inflammatory factors,enhance immunologic function,thus,which is helpful to patient's recovery.
Keywords：severe acute pancreatitiscontinuous blood purificationDachengqi decoctiontreatment outcome
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1457-1460 )