Correlation between the changes of TGF-β1,P53 protein levels in peripheral blood and clinical characteristics in patients with breast cancer

doi:10.3969/j.issn.1002-7386.2017.10.003

Abstract：Objective To observe the changes of TGF-β1,P53 protein levels in peripheral blood of patients with breast cancer in order to explore the correlation between the two factors and clinical characteristics of nreast cancer.Methods Eighty patients with breast cancer were enrolled as breast cancer group,and 30 patients with hyperplasia of mammary glands were served as mammary glands hyperplasia group (MGH group).The expression levels of TGF-β 1 and P53 protein in peripheral blood of patients with breast cancer before and after treatment were detected by enzyme linked immunosorbent assay (ELISA),which were compared with those in patients with hyperplasia of mammary glands.Moreover the correlation between the changes of expression levels of TGF-β1,P53 protein before and after treatment and clinical characteristics of breast cancer was analyzed.Results The expression levels of TGF-β1 and P53 protein in breast cancer group were significantly higher than those in MGH group (P<0.05).After treatment,the expression levels of TGF-β1 and P53 protein were obviously decreased (P<0.05).The expression levels of TGF-β1 and P53 protein were closely correlated to histological grading and axillary lymph node metastasis of breast cancer (P<0.05),however,which were not related with the expression levels of estrogen receptor in breast cancer tissues (P>0.05).Moreover the expression of TGF-β1 was positively correlated to that of P53 protein (r=0.348,P<0.01).Conclusion The expression levels of TGF-β1and P53 protein in peripheral blood of patients with breast cancer are obviously increased,moreover,which are closely correlated to histological grading and axillary lymph node metastasis of breast cancer,therefor,which can provide new targets and ideas for clinical treatment of breast cancer.