Effects of vinpocetine on hemorheological indexes and platelet-related parameters in patients with sudden deafness
LI Ming
LI Xiuchi
CHEN Fen
Abstract：Objective To investigate the effects of vinpocetine on hemorheology and platelet-related parameters in patients with sudden deafness.Methods Fifty-four patients with sudden deafness who were admitted and treated in our hospital from January 2012 to December 2015 were enrolled in the study.According to random number method,these patients were divided into control group and observation group,with 27 patients in each group.The patients in observation group given vinpocetine (20mg/time/d) by intravenous injection,however,the patients in control group were given Danshen injection (20ml/time/d) by intravenous drip,with a treatment course of 7 days, continuous 3 treatment courses for both groups.The changes of hemorheological indexes and platelet-related parameters before treatment, after 7-day,14-day and 21-day treatment were observed and compared between two groups.Results After after 7-day,14-day and 21-day treatment,the whole blood viscosity,whole blood low shear viscosity,plasma viscosity in observation group were significantly lower than those in control group (P<0.05).After after 7-day,14-day and 21-day treatment,the red blood cell aggregation index,erythrocyte sedimentation rate equation K value and red cell electrophoresis index in observation group were significantly lower than those in control group (P<0.05).Moreover the levels of CD62p,CD61,VWF,PAR in observation group were significantly lower than those in control group (P<0.05).Conclusion The vinpocetine in treatment of sudden deafness can effectively improve hemorheological indexes and platelet-related parameters,which plays a positive role in improving microcirculation of aural region.
Keywords：vinpocetinesudden deafnesshemorheologyplatelet
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 1341-1343 )