The significance of CEA and AFP,CA242 in pathological diagnosis and prognostic evaluation of gastric cancer

doi:10.3969/j.issn.1002-7386.2017.09.014

Abstract：Objective To explore the significance of carcinoembryonic antigen (CEA), alpha-fetoprotein (AFP) and gastrointestinal cancer antigen (CA242) in pathological diagnosis and prognostic evaluation of gastric cancer.Methods Seventy-one patients with gastric cancer who were diagnosed definitely in our hospital from January 2012 to June 2013 were selected as gastric cancer group,at the same time, the other 71 patients with gastric benign lesions were served as benign lesion group,moreover, the 71 healthy subjects were served as control group.The serum levels of CEA,AFP and CA242 were detected and compared among the three groups.Results The serum levels of CEA,CA242 and AFP in gastric cancer group were significantly higher than those in benign lesion group and control group (P<0.01).The sensitivity, specificity, accuracy,positive predictive value, negative predictive value of CEA in diagnosis of gastric cancer were 96.07%, 75.82%, 83.1%, 69.01%,97.18%,respectively,which of CA242 were 94%, 73.91%, 80.99%, 66.2%, 95.77%, respectively,which of AFP were 80%,56.41%, 60.56%,28.17%,92.96%,respectively.Among the patients receiving follow-up, the patients with positive CEA,CA242 and AFP were more than the patients with negative CEA,CA242 and AFP ,however, among the cancer-free survival patients,the proportion of patients with positive CEA,CA242and AFP was lower than that of patients with negative CEA,CA242 and AFP.Conclusion The CEA,CA242 and AFP can be used as sensitive indexes in early diagnosis of gastric cancer,which can also be used for prognostic assessment.