Comparative analysis of progesterone or phloroglucinol combined with chorionic gonadotropin in treatment of threatened abortion

CAI Yanhong

doi:10.3969/j.issn.1002-7386.2017.09.007

Abstract：Objective To compare the therapeutic effects of progesterone or phloroglucinol combined with human chorionic gonadotropin (HCG) on threatened abortion.Methods One hundred patients with threatened abortion who were admitted and treated in our hospital from January 2012 to January 2016 were divided into phloroglucinol group (n=50) and progesterone group (n=50) according to different medication modes.The patients in both groups were treated by chorionic gonadotropin injection during treatment.The therapeutic effects,adverse reactions and pregnancy outcome were observed and compared between two groups.Results As compared with those before treatment,the serum levels of progesterone (P),estradiol (E2) and HCG were obviously improved after treatment in both groups (P<0.05),however the serum levels of P,E2 and HCG in phloroglucinol group were significantly higher than those in progesterone group (P<0.05).Moreover the abdominal pain extinction time and hematoma absorption time in phloroglucinol group were obviously shorter than those in progesterone group (P<0.05),but there was no significant difference in the incidence rate of adverse reactions between two groups (P>0.05), moreover, there was no significant difference in preterm labor rate between two groups (P>0.05).Besides the abortion rate in phloroglucinol group was less than that in progesterone group,but the full-term birth rate in phloroglucinol group was significantly higher than that in progesterone group (P<0.05).Conclusion The therapeutic effects of phloroglucinol combined with HCG on threatened abortion are quite significant,which can effectively relieve clinical symptoms, improve pregnancy outcome,with good safety, therefor, which is worth using widely in clinical practice.