Serum levels and clinical significance of CC-16 in patients with acute respiratory distress syndrome

HU Zhong; WANG Jin; ZHENG Juan

doi:10.3969/j.issn.1002-7386.2017.09.003

Abstract：Objective To investigate the serum levels of Clara cell protein-16 (CC-16) in patients with acute respiratory distress syndrome (ARDS), and to explore its clinical value in diagnosis of ARDS.Methods Sixty-two patients with ARDS who were treated in our hospital from October 2011 to February 2016 were enrolled as ARDS froup, and 44 healthy subjects were enrolled as control group.The general situations of patients were recorded,and pulmonary function and arterial blood gas analysis indexes were detected.The levels of CC-16 and BNP were detected by ELISA.The correlation between CC-16 and clinical parameters was analyzed,moreover, the ROC curve was used to evaluate the diagnostic value of CC-16 in patients with ARDS.Results The levels of CC-16 in ARDS group were significantly higher than those in control group [(19.89±8.59) ng/ml vs (11.04±4.77)ng/ml,P<0.01].The levels of CC-16 in patients with different degree of ARDS were in order (from higher levels to lower levels):(24.46±7.58)ng/ml in severe ARDS group,(19.64±7.01)ng/ml in moderate ARDS group and (12.94±6.08)ng/mL in mild ARDS group.Among ARDS group,the levels of CC-16 were positively correlated with APACHEⅡscore (r=0.583,P<0.01),SOFA score (r=0.536,P<0.01),BNP (r=0.427,P<0.01),however,which were negatively correlated to PaO2/FiO2 (r=0.614,P<0.01).The AUC of CC-16 alone in diagnosis of ARDS was 0.800 (95%CI:0.719~0.882),but AUC of CC-16 combined with BNP in diagnosis of ARDS was 0.834 (95%CI: 0.759~0.909).Conclusion The serum levels of CC-16 in patients with ARDS are significantly increased, moreover ,the clinical value of CC-16 alone or CC-16 combined with BNP in diagnosis of ARDS is higher.