Effects of different levels of blood glucose on inflammation reaction status and therapeutic effects in PICU in children patients with sepsis

doi:10.3969/j.issn.1002-7386.2017.09.002

Abstract：Objective To investigater the effects of different levels of blood glucose on inflammation reaction status and therapeutic effects in pediatric intensive care unit (PICU) in children patients with sepsis.Methods Sixty-three children patients with sepsis who were admitted and treated in PICU of our hospital from January 2014 to January 2016 were divided into group A,group B,group C according to random number table,with 21 patients in each group.The blood glucose levels in group A were controlled in 4.4~6.1mmol/L,and 6.2~8.3mmol/L in group B, 8.4~10.0mmol/L in group C.The inflammation reaction status and therapeutic effects were observed and compared among the three groups.Results On 1 day and 3 days after put into PICU,the serum levels of TNF-αin group A were significantly lower than those in group B and group C (P<0.05).On 1 day after put into PICU,the serum levels of IL-4 in group A were significantly higher than those in group B and group C,however, on 3 days after put into PICU,the serum levels of IL-4 in group A were significantly lower than those in group B and group C (P<0.05).On 3 days and 7 days after put into PICU,the serum levels of Wnt5a in group A were significantly lower than those in group B and group C (P<0.05).The case fatality rate and incidence rate of MODS in group A were lower than those in group B and group C,but there were no significant differences among them (P>0.05).There was significant difference in treatment time in PICU among three groups (P<0.05), however, there were no significant differences in incidence rates of hypoglycemia among three groups (P>0.05).Conclusion The blood glucose levels controlled in 4.4~6.1mmol/L help to inhibit the release of TNF-α and Wnt5a in children patients with sepsis,to stimulate IL-4 production,reduce inflammation reaction and improve therapeutic effect, therefor,which is worth using widely in clinical practice.