Expression and clinical significance of WT1 in colon cancer
GONG Yong
TONG Qiaoyun
ZHENG Shihua
Abstract：Objective To observe the expression of WT1 in colon carcinoma, and to explore its clinical significance.Methods The expression levels of WT1 in 48 cases of colon carcinoma and 14 cases of normal colon tissues were detected by immunohistochemistry and semi quantitative RT-PCR.The correlation between the expression of WT1 and clinical pathological features as well as patient's prognosis was analyzed.Results The positive expression rates of WT1 in colon carcinoma were significantly higher than those in normal colon tissues ( P <0.05).The expression of WT1 was not correlated to patient's age and sex,differentiation degree of tumor ( P >0.05),however,which was related with TNM staging and lymph node metastasis of tumor ( P <0.05).The survival analysis showed that there was no significant difference in survival time between patients with WT1 positive expression and patients with WT1 negative expression ( P >0.05).Conclusion The high expression of WT1 may play an important role in the pathogenesis and development of colon cancer,which may provide an new way for treatment of colon cancer.
Keywords：WT1colon cancer
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 1176-1178 )