Expression and clinical significance of p53 and Ki67 in triple negative breast cancer

JIANG Li; ZHANG Jianping

doi:10.3969/j.issn.1002-7386.2017.08.012

Abstract：Objective To investigate the expression and clinical significance of p 53 and Ki67 in patients with triple negative breast cancer.Methods One hundred and two patients with infiltrating breast carcinoma who were diagnosed by pathological examination in our hospital were randomly divided into two groups ,in which 51 patients with triple negative breast cancer were in observation group,however, the other 51 patients with non -triple negative breast cancer were in control group .The expression levels of p53 and Ki67 were detected and compared between two groups .Moreover the correlation between the expressions of p53,Ki67 and patient's age,histological grading,vascular invasion,tumor diameter and lymph node metastasis was analyzed,at the same time, the correlation between the expressions of p53,Ki67 and patient's survival rate was analyzed. Results The positive expression rates of p53 and Ki67 in observation group were significantly higher than those in control group ( P <0.05).The expression of p53 in observation group was closely correlated to histological grading ,vascular invasion,tumor diameter and lymph node metastasis ( P <0.05),and the expression of Ki67 was closely related with histological grading ( P <0.05).Among 102 patients with infiltrating breast carcinoma,the survival rate in patients with positive expression of p53 was obviously lower than that of patients with negative expression of p 53,moreover, the survival rate in patients with positive expression of ki67 was significantly lower than that of patients with negative expression of Ki 67 ( P <0.05).Among the patients with triple negative breast cancer , the survival rate in patients with positive expression of p53 and ki67 was significantly lower than that of patients with negative expression of p 53 and Ki67 ( P <0.05).Conclusion The positive expression rates of p53 and Ki67 are higher in patients with triple negative breast cancer ,and the expressions of p53 and Ki67 play an important role in the ability of tumor proliferation ,malignant degree of tumor and patient's prognosis.