Therapeutic effects of hepatitis B anti-fibrosis decoction combined with entecavir on liver cirrhosis due to hepatitis B and their influence on inflammatory factors

ZHU Tong; WANG Bing

doi:10.3969/j.issn.1002-7386.2017.08.008

Abstract：Objective To observe the therapeutic effects of hepatitis B anti -fibrosis decoction combined with entecavir on liver cirrhosis due to hepatitis B and their influence on inflammatory factors .Methods Ninety -four patients with liver cirrhosis due to hepatitis B at compensation period who were treated in our hospital from January 2012 to December 2015 were randomly divided into observation group and control group ,with 47 patients in each group.The patients in control group were treated by entecavir, however, the patients in observation group,on the basis of control group,were treated by hepatitis B anti -fibrosis decoction.The therapeutic effects, the changes of portal vein diameter, thickness of spleen, Stiffness value,hepatitis B virus DNA (HBV-DNA), platelet-derived growth factor-BB (PDGF-BB), matrix metalloproteinase 1 (MMP1),tissue inhibitor of matrix metalloproteinase 1 (TIMP 1), TIMP1/MMP1, interleukin (IL)-6, IL-8, interferon (INF)-γand IL-10 before and after treatment were observed and compared between two groups .Results The total effective rate was 87.23% in observation group,which was significantly higher than that (68.09%) in control group (χ2 =3.924, P <0.05).Before treatment there were no significant differences in the portal vein diameter , spleen thickness, Stiffness value, the levels of HBV-DNA, PDGF-BB, MMP1, TIMP1, TIMP1/MMP1, IL-6, IL-8, INF-γand IL-10 between two groups ( P >0.05),however,after treatment,the portal vein diameter, thickness of spleen, Stiffness value,the levels of HBV-DNA, PDGF-BB,TIMP1, TIMP1/MMP1, IL-6 and IL-8 were significantly decreased in both groups ,as compared with those before treatment (P <0.01),but the levels of MMP1, INF-γand IL-10 were significantly increased (P<0.01).Moreover the decreasing or increasing levels of portal vein diameter, spleen thickness, Stiffness value, PDGF-BB, MMP1, TIMP1, TIMP1/MMP1,IL-6, IL-8, INF-γand IL-10 in observation group were more significant than those in control group(P <0.01), however,there were no significant differences in the levels of HBV -DNA between two groups ( P >0.05).Conclusion Therapeutic effects of hepatitis B anti -fibrosis decoction combined with entecavir on liver cirrhosis due to hepatitis B are quite significant ,which may be correlated to the effects of hepatitis B anti -fibrosis decoction in improving liver cell damage , alleviating liverfibrosis and correcting body's inflammatory cytokine disorder.