Study of the inhibitory effects of compound bismuth aluminate granules on IL-1β induced relapse models of acetic acid gastric ulcer in rats CHEN Wanzhen
Abstract：Objective To investigate the inhibitory effects of compound bismuth aluminate granules (Debitai) on IL-1β induced relapse models of acetic acid gastric ulcer in rats.Methods The rats were randomly divided into blank group,model group,rabeprazole group and Debitai group.The rats models with acetic acid induced gastric ulcer were interfered by rabeprazole,and the healing rats were given 0.9% sodium chloride solution,rabeprazole,Debitai+rabeprazole suspension by gavagee for 7 weeks,then IL-1β was injected intraperitoneally to induce relapse models of gastric ulcer.The serum indexes and pathological indexes were detected in all the groups.Results There were significant differences in relapse rates and gastric ulcer indexes between model group and rabeprazole group,Debitai group ( P <0.01).As compared with those in model group,the serum levels of PGE2 and EGF in rabeprazole group and Debitai group were significantly increased ( P <0.05 or P<0.01),however,the serum levels of GAS were significantly decreased ( P <0.05 or P <0.01).The serum levels of PGE2 and EGF in Debitai group were significantly increased,but the serum levels of GAS were significantly decaresed ( P <0.05 or P <0.01).The gastric mucous membrane morphous and histopathological morphous in rabeprazole group and Debitai group were superior to those in model group.Conclusion The Debitai combined with rabeprazole has inhibitory effects on the relapse of IL-1β induced acetic acid gastric ulcer in rats.
Keywords：compound bismuth aluminate granulesIL-1βgastric ulcerrelapse
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1148-1150,1154 )