Relationship between serum uric acid and metastasis or non-metastasis of rectal cancer
Abstract：Objective To investigate the role of uric acid ( UA) in assessing rectal cancer metastasis .Methods Four hundred and seventy-five patients with rectal cancer were divided into metastasis group ( n =108 ) and non-metastasis group ( n =367 ) .The clinical data were analyzed and compared between two groups .Results There were significant differences in tumor diameter,serum levels of carcino-embryonic antigen (CEA) and C-reactive protein (CRP) between two groups ( P <0.05).As compared with those in patients without lymphatic metastasis ,the serum levels of UA in patients with lymphatic metastasis were significantly increased ( P <0.05).In patients with lymphatic metastasis of rectal cancer ,the serum levels of UC were positively correlated to those of creatinine (Cr),CRP and CEA ( r =0.281, P <0.05;r =0.312, P <0.01;r =0.294, P <0.05).The multiple regression model analysis showed that the serum level of UA was an important index to predict lymphatic metastasis of patients with rectal cancer ,which was independent of CRP ,CEA and tumor diameter (OR=1.035,CI95%:1.013 ~1.057, P <0.05).ROC curve analysis showed that the area under curve of serum UA in-metastatic rectal cancer was 0.803,with sensitivity and specificity being 0.803, 0.739,respectively.Conclusion The serum UA may become an new marker in assessing tumour metastasis in patients with rectal cancer .
Keywords：rectal cancerserum uric acidtumour metastasiscarcino-embryonic antigen
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 1005-1007 )