The influences of atomization inhalation combined with non-invasive positive pressure ventilation on immune function and platelet derived growth factor-β in patients with COPD complicated by respiratory failure
WANG Jia
MING Hui
Abstract：Objective To investigate the influences of atomization inhalation combined with non-invasive positive pressure ventilation ( NPPV) on immune function and platelet derived growth factor-β( PDGF-β) in patients with chronic obstructive pulmonary disease ( COPD ) complicated by respiratory failure .Methods Eighty -six patients with COPD complicated by respiratory failure who wer e admitted and treated in our hospital from 2013 to 2015 were randomly divided into observation group ( n =43) and control group ( n =43).The patients in control group were treated by routine atomization inhalation ,however , the patients in observation group , on the basis of control group , were treated by NPPV .The immune function indexes (IgA,IgG,C3), PDGF-βlevels and therapeutic effects were observed and compared between two groups. Results After treatment,the SGRQ score, MMRC score,6-min walking score in observation group were significantly lower than those in control group (53.01 ±4.28 vs 55.71 ±4.09,2.79 ±0.31 vs 3.05 ±0.36,1.33 ±0.32 vs 1.51 ±0.39, respectively, P <0.05).After treatment, the FEV1% value and PaO2 value in observation group were significantly higher than those in control group (42.22 ±3.07 vs 40.05 ±3.01,66.93 ±2.38 vs 61.50 ±2.91,respectively),however, PaCO2 values were significantly lower than those in control group (51.78 ±2.43 vs 56.03 ±3.15).The levels of IgA,IgG,C3 in observation group were significantly lower than those in control group (2.52 ±0.9 vs 1.72 ±0.8,14.7 ±3.2 vs 11.7 ±2.5, 1.50 ±0.4 vs 1.25 ±0.5,respectively).After treatment, PDGF-βlevels were obviously decreased in both groups ,moreover, the PDGF-βlevels in observation group were significantly lower than those in control group ( P <0.05).During treatment,the death rate in observation group was lower than that in control group ,but there was no significant difference between two groups ( P >0.05).Conclusion The atomization inhalation combined with non-invasive positive pressure ventilation can obviously improve pulmonary function of patients with COPD complicated by respiratory failure ,and can regulate immune function and improve effectively patient ' s prognosis .
Keywords：non-invasive positive pressure ventilationCOPDrespiratory failureimmune functionplatelet derived growth factor
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 998-1001 )