The changes of expression levels of amyloid precursor-like protein 2 in endometrial carcinoma and its effects on patient' s prognosis

Wu Yuan

doi:10.3969/j.issn.1002-7386.2017.07.009

Abstract：Objective To investigate the expression of amyloid precursor-like protein 2 ( APLP2 ) in endometrial carcinoma, and to explore its effects on patient ' s prognosis in order to provide reference for improving the prognosis of patients.Methods The xpression levels of APLP2 were detected by immunohistochemistry in 38 cases of endometrial carcinoma tissues and 42 cases of normal endometrium tissues .Moreover the clinical data and follow-up results were collected to analyze the correlation between expression of APLP 2 and clinical data .Besides these patients were divided into APLP 2 positive expression group and APLP 2 negative expression group ,and the survival status of patients was observed and compared between two groups .Results The positive expression rate of APLP 2 in endometrial carcinoma tissues was 28.95%,which was significantly lower than that (85.71%) in normal endometrial tissues ( P <0.05).The positive expression of APLP2 was correlated with muscular layer infiltration , estrogen receptor expression and differentiation degree of endometrial carcinoma (P<0.05),however,which was not correlated to patien 's age,FIGO staging,pathological type,lymph node metastasis ( P >0.05).After 6 ~36 month follow -up,the survival rate in APLP2 positive expression group was 81.48%,which was significantly higher than that (55.45%) in APLP2 negative expression group ( P <0.05).Conclusion The low-expression of APLP2 exists in patients with endometrial cancer ,which is correlated to muscular layer infiltration and differentiation degree of tumor,moreover,which can be regarded as as an important index to evaluate patient 's prognosis.