Clinical value of detection of serum levels of CEA and CA15-3 in peripheral blood of patients with breast cancer before and after surgery

doi:10.3969/j.issn.1002-7386.2017.06.015

Abstract：Objective To investigate the changes and clinical significance of detection of serum levels of carcinoembryonic antigen (CEA) and glycoprotein antigen 15-3 (CA15-3) in peripheral blood of patients with breast cancer before and after surgery.Methods Seventy-eight patients with breast cancer who received surgical treatment in our hospital from January 2013 to June 2015 were served as breast cancer group,at the same time,60 patients with benign breast diseases were selected as benign disease group,moreover 60 healthy subjects were served as control group.The serum levels of CEA and CA15-3 were detected and compared among the three groups,The serum levels of CEA and CA15-3 in patients with breast cancer before and after operation and in patients with or without relapse and metastasis were observed and compared,furthermore,the diagnostic value of detection of CEA,CA15-3 levels in evaluating relapse and metastasis of breast cancer were analyzed.Results The serum levels of CEA and CA15-3 in breast cancer group were significantly higher than those in benign disease group and control group (P ＜ 0.05).On 4 weeks after operation,the serum levels of CA15-3 and CEA in breast cancer group were significantly lower than those before operation (P ＜ 0.05).Moreover the serum levels of CEA and CA15-3 in patients with relapse and metastasis were significandy higher than those of patients without relapse and metastasis (P ＜0.05).The sensitivity and accuracy of combination detection of CEA and CA15-3 were significantly higher than those of single detection (P ＜ 0.05).Conclusion The serum levels of CEA,CA15-3 in patients with breast cancer are significantly increased,however,which are obviously decreased after operation,but the serum levels of CEA,CA15-3 in patients with postoperative relapse and metastasis are significantly increased,moreover,the combination detection of CEA and CA15-3 has important clinical value for evaluating relapse and metastasis of breast cancer.