Therapeutic effects and safety of Wenxin granules combined with amiodarone and perindopril on senile paroxysmal atrial fibrillation
CAI Yanping
WANG Feiyu
Abstract：Objective To investigate the therapeutic effects and safety of Wenxin granules combined with amiodarone and perindopril on senile paroxysmal atrial fibrillation.Methods One hundred and sixteen elderly patients with paroxysmal atrial fibrillation who were treated in department of cardiology of our hospital from September 2014 and January 2016 were randomly divided into control group and observation group,with 58 patients in each group.The patients in control group were treated by amiodarone combined with perindopril,however,the patients in observation group,on the basis of control group,were treated by Wenxin granules.After treatment the therapeutic effects,safety and adverse reactions were observed and compared between two groups.Results The effective rate in observation group was 90.57％,which in control group was 67.27％,there was a significant difference between two groups (P ＜ 0.05).Before treatment there were no significant differences in ventricular rate,frequency of atrial fibrillation,left ventricular end-diastolic diameter (LVEDD),left atrial diameter (LAd),left atrial maximum volume (LAVmax),P wave maximum time limit (Pmax),P wave dispersion degree (Pd),A peak value flow velocity (VA) (P ＞ 0.05).There were significant differences in these indexes mentioned above in observation group before treatment and after treatment,however,in control group,except for LAd,there were significant differences in these indexes before treatment and after treatment,moreover,there were significant differences in these indexes after treatment between two groups (P ＜ 0.05).There were 3 patients with adverse reactions in observation group,with the incidence rate of adverse reactions being 5.66％,however,there were 15 patients with adverse reactions in control group,with the incidence rate of adverse reactions being 27.27％,there was a significant difference between two groups (P ＜ 0.05).Conclusion Therapeutic effects of Wenxin granules combined with amiodarone and perindopril on senile paroxysmal atrial fibrillation are obvious and superior to those of routine therapy,with better safety,therefor,which is worth researching and using further.
Keywords：Wenxin granulesamiodaroneperindoprilsenile paroxysmal atrial fibrillation
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 847-849,853 )