Clinical significance of combination monitoring of D-dimer, hs-CRP and MMP-9 levels in patients with acute ischemic cerebral infarction

ZHOU Hua; XIAO Yu

doi:10.3969/j.issn.1002-7386.2017.06.011

Abstract：Objective To investigate the clinical significance of combination monitoring of D-dimer,hypersensitive C-reactive protein,(hs-CRP) and matrix metalloproteinases-9 (MMP-9) levels in patients with acute ischemic cerebral infarction.Methods Eighty patients with acute ischemic cerebral infarction who were admitted and treated in our hospital from March 2014 to March 2016 were enrolled as case group,at the same time,the other 80 healthy subjects were served as control group.The serum levels of D-dimer,hs-CRP and MMP-9 were detected in both groups,moreover,the patients in case group were redivided into mild case group,moderate case group and severe case group.Besides the correlation among D-dimer,hs-CRP and MMP-9 in patients with acute ischemic cerebral infarction was analyzed.Results The serum levels of D-dimer,hs-CRP and MMP-9 in case group were (1.49 ± 0.12) mg/L,(11.38 ± 2.12) mg/L,(332.27 ± 54.62) μg/L,respectively,which were significantly higher than those [(0.25 ± 0.04) mg/L,(2.14 ± 0.51) mg/L,(124.68 ± 27.59) μg/L],respectively in control group (P ＜ 0.05).Moreover the serum levels of D-dimer,hs-CRP and MMP-9 in mild case group were (68 ± 0.14) mg/L,(3.16 ± 0.87) mg/L,(227.48 ± 43.26) μg/L,respectively,which were significantly lower than those [(1.13 ± 0.25) mg/L,(7.54 ± 1.3) mg/L,(325.69 ± 62.74) μg/L],respectively in moderate case group and those [(1.54 ±0.37) mg/L,(13.49 ± 1.50) mg/L,(497.23 ± 74.35) μg/L] in severe case group (P ＜ 0.05).Besides there was a positive correlation among the serum levels of D-dimer,hs-CRP and MMP-9 (P ＜ 0.05).Conclusion The combination monitoring of D-dimer,hs-CRP and MMP-9 levels is helpful for the diagnosis of acute ischemic cerebral infarction,moreover,which can evaluate the development of the diseases to guide clinical treatment.