Study on the correlation between ADC value and age, sex in white matter region of precentral gyrus, postcentral gyrus during normal brain aging
Abstract：Objective Using MR diffusion weighted imaging (DWI) to investigate the correlation between apparent diffusion coefficient (ADC) value and age,sex in white matter region of precentral gyrus,postcentral gyrus during normal brain aging.Methods One hundred and twenty right-handedness healthy volunteers,according to their age and sex,were divided into young female group or young male group (≤44 years) and middle-age and older age female group or middle-age and older age male group (＞ 45 years),with 30 subjects in each group.All the subjects were examined by magnetic resonance imaging (MRI) and diffusion weighted imaging (DWI),setting the regions of interest as ROI (22 ± 2)mm2,and selecting the regions of interest in cerebral white matter region,then the ADC values in white matter region of left precentral gyrus,right precentral gyrus,left postcentral gyrus,right postcentral gyrus were detected and compared among the four groups.Results There were significant differences in ADC values in white matter region of left precentral gyrus,right precentral gyrus,left postcentral gyrus,right postcentral gyrus at the same sex among different age groups (P ＜ 0.05).There were significant differences in ADC values in white matter region of right precentral gyrus between young female group and young male group (P ＜ 0.05).However there were significant differences in ADC values in white matter region of left postcentral gyrus between middle-age and older age female group and middle-age and older age male group (P ＜ 0.05).Conclusion During normal brain aging,the ADC values in white matter region of left precentral gyrus,right precentral gyrus,left postcentral gyrus,right postcentral gyrus are positively correlated to age,with the age increasing gradually,the ADC values in white matter region of right precentral gyrus in young males are greater than those in young females,moreover,,the ADC values in white matter region of left postcentral gyrus in middle age and older age males are greater than those in middle age and older age females.
Keywords：brain agingprecentral gyruspostcentral gyrusMR diffusion weighted imagingADC valueage-related analysis
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 813-817 )