Therapeutic effects of loratadine and budesonide combined with subcutaneous specific immunotherapy on allergic rhinitis
WU Jingjing
FU Manni
Abstract：Objective To observe the immunomodulatory effects of loratadine and budesonide combined with subcutaneous specific immunotherapy on allergic rhinitis , and to evaluate its clinical efficacy .Methods Eighty-four patients with allergic rhinitis who were treated in our hospital were randomly divided into conventional therapy group ( n =42) and observation group ( n =42).The patients in conventional therapy group were treated by loratadine and budesonide nasal spray,however, the patiens in observation group were treated by loratadine and budesonide nasal spray combined with subcutaneous specific immunotherapy.of the levels of Th17 and Treg cells were detected by flow cytometry,and the expression levels of of IgE, IL-17, and IL-10 was detected by ELISA assay.Results Before treatment, there were no significant differences in the levels of Th17,Treg cells IgE,IL-17 and IL-10 between two groups ( P >0.05).After treatment,the levels of Th17 cells were significantly decreased in both groups ( P <0.05),however, the levels of Treg cells were significantly increased ( P <0.05).However the regulatory effects on Th17 and Treg cells in observation group were superior to those in control group ( P <0.05).After treatment,the expression levels of IgE and IL-17 were significantly decreased in both groups ( P <0.05),however, the levels of IL-10 were significantly increased ( P <0.05).Moreover the regulatory effects on the expressions of IgE,IL-17,IL-10 in observation group were superior to those in control group ( P <0.05).The expression of IgE was positively correlated to that of IL -17 ( r =0.412, P <0.05),however,which was negatively correlated with that of IL-10 ( r =0.354, P <0.05).Before treatment,there were no significant differences in symptom scores and medication scores between two groups ( P >0.05),however, after treatment,the symptom scores were significantly decreased in both groups ( P <0.05).Furthermore the improvement effects in observation group were superior to those in control group ( P <0.05).After treatment,medication scores in control group were not changed obviously ,as compared with those before treatment ( P >0.05),but the medication scores in observation group were significantly decreased after treatment ( P <0.05). Conclusion The specific immunotherapy can regulate the imbalance of Treg /Th17 cells in patients with allergic rhinitis ,and can reduce the dosage of anti histamine and local hormone drugs ,with obvious therapeutic effects .
Keywords：allergic rhinitisspecific immunotherapyTh17 cellsTreg cells
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 704-706 )