Therapeutic effects of propranolol on portal hypertension and the significance of width changes of portal vein

doi:10.3969/j.issn.1002-7386.2017.05.015

Abstract：Objective To observe the therapeutic effects of propranolol on portal hypertension and the clinical significance of measurement of portal vein width .Methods The clinical data about 68 patients with portal hypertension in cirrhosis decompensation period who were admitted and treated in our hospital from January 2013 to December 2015 were retrospectively analyzed.According to the treatment way,these patients were divided into propranolol group ( n =42) and control group ( n =26),the patients in both groups were treated by conventional therapy ,however,the patients in propranolol group,on the basis of control group,were treated by propranolol .The therapeutic effects and changes of portal vein width were observed and compared between two groups .Results Before treatment,there were no significant differences in the vein width , WHVP,FHVP,HVPG between two groups ( P >0.05).After treatment,the vein width,WHVP,HVPG were significantly decreased in both groups ( P <0.05),moreover,which in propranolol group were significantly lower than those in control group ( P <0.05).There was a correlation between portal vein width and HVPG ( r =0.617, P <0.05) before treatment, so was after treatment ( r =0.574, P <0.05).Conclusion The propranolol has obvious therapeutic effects on portal hypertension in liver cirrhosis decompensation period , moreover, portal vein width can reflect the changes of portal hypertension of patients,which can also reflect clinical therapeutic effects .