Changes and clinical significance of platelet count,platelet specific volume and platelet distribution width in patients with lung cancer before and after radical operation
ZHAO Hua
JIA Yongmei
Abstract：Objective To observe the changes of platelet count (PLT), platelet specific volume (PCT) and platelet distribution width ( PDW) in patients with lung cancer before and after radical operation , and to explore its clinical significance.Methods Seventy-three patients with lung cancer who received radical operation were divided into IA group (n =41) and IB group (n =32) according to TMN,moreover, 50 healthy subjects were served as control group .On 7 days after surgery,the platelet related parameters in peripheral blood were detected ,including PLT,PCT and PDW.All the subjects were followed up for 5 years,with the frequency being once in 6 months.The survival duration and KPS scores of patients were statistically analyzed.Results The levels of PLT,PCT and PDW in patients with lung cancer were higher than those in control group.After operation,the levels of PCT,PLT and PDW in IA group and IB group were significantly higher than those in control group ( P <0.05).The levels of PLT and PCT in patients with small cell carcinoma were relatively higher ,however, the levels of PDW in patients with large cell carcinoma were relatively higher ( P <0.05).The operation duration and the cases with postoperative complications in IA group were fewer than those in IB group ,however, the lymph nodes removed during operation in IA group were more than those in IB group ( P <0.05).Conclusion The conventional radical operation in treatment of lung cancer can effectively change platelet indexes ,in which PLT,PCT and PDW are obviously decreased.
Keywords：lung cancer radical resectionplateletmean platelet volumeplatelet distribution width
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 691-693,697 )