Expression and clinical significance of exhaled nitric oxide and serum total IgE in patients with asthma-COPD overlap syndrome and patients with COPD

LIANG Yueming; LI Minjing

doi:10.3969/j.issn.1002-7386.2017.05.010

Abstract：Objective To investigate the expression and clinical significance of exhaled nitric oxide (FeNO) and serum total IgE in patients with asthma-COPD overlap syndrome (ACOS) or chronic obstructive pulmonary disease (COPD). Methods Forty -two patients with ACOS (ACOS group) and 178 patients with COPD including 50 patients in diastolation positive group and 128 patients in diastolation negative group according to bronchial diastolation test as well as 52 patients with chronic cough (chronic cough group) who were treated in our hospital from September 2014 to September 2015 were enrolled in the study.The pulmonary ventilation function of patients , FeNO and serum total IgE levels were observed and compared among the four groups.Results The pulmonary ventilation function parameters including FEV 1 /prediction value %,FVC/prediction value %,FEV1/FVC in ACOS group, diastolation positive group and diastolation negative group were significantly lower than those in chronic cough group ( P <0.01),however,there were no significant differences among the former three groups ( P >0.05).The expression levels of FeNO and serum total IgE were ACOS group >diastolation negative group >diastolation positive group >chronic cough group ( P <0.01).The correlation analysis showed that there no obvious correlation between FeNO,serum total IgE levels and pulmonary ventilation function parameters including FEV 1/prediction value %,FVC/prediction value %,FEV1 /FVC ( P >0.05).Conclusion The expressin levels of FeNO and serum total IgE are increased in patients with ACOS,which may become objective indexes to diagnose ACOS .The patients with the increase of FeNO and /or serum total IgE,or COPD patients with diastolation test being positive should pay much attention to occurrence of ACDS.