Analysis for the long-term effects of bisoprolol combined with Shenmai injection on coronary heart disease with heart failure
HOU Min
Abstract：Objective To observe the long-term effects of bisoprolol combined with Shenmai injection on coronary heart disease with heart failure .Methods One hundred and fifty patients with coronary heart disease complicated by heart failure who were treated in our hospital from March 2012 to March 2015 were randomly divided into research group and control group,with 75 patients in each group .The patients in control group were treated by conventional therapy , however, the patients in research group ,on the basis of control group , were treated by bisoprolol combined with Shenmai injection , with a treatment course of one month for both groups .Then the left ventricular ejection fraction ( LVEF) ,left ventricular end systolic volume (LVESV) and left ventricular end diastolic volume (LVEDV) were detected by ultrasonic cardiogram .The therapeutic effects, inflammatory factors levels and side effects were observed and compared between two groups to evaluate the application value of bisoprolol combined with Shenmai injection in treatment of coronary heart disease complicated by heart failure .Results The total effective rate in research group was 92.00%,which was significantly higher than that in control group (x2 =4.485, P <0.05).After treatment, the serum levels of IL-6 and IL-8 were significantly decreased in both groups ( P <0.05), moreover, the decrease extent in research group was more obvious than that in control group ( P <0.05).Moreover after treatment, the levels of LVEF, LVESV and LVEDV were obviously improved in both groups , furthermore, which in research group were superior to those in control group ( P <0.05).During treatment,only 3 patients in research group had adverse reactions, with incidence rate of side effects being 4.00%, however, 10 patients in control group had adverse reactions ,with incidence rate of side effects being 13 .33%, there was a significant difference between two groups (x2 =4.127, P <0.05).Conclusion The bisoprolol combined with Shenmai injection has better clinical efficacy in treatment of coronary heart disease complicated by heart failure ,which can significantly improve patient ' s clinical symptoms and enhance patient's cardiac function,thus,which is of great clinical application value .
Keywords：bisoprololShenmai injectioncoronary atherosclerotic heart diseaseheart failure
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 537-539,544 )