Dredictive value of serum levels of cortisol and neuropeptide Y in predicting malignant cerebral infarction in patients with cerebral infarction
LI Yong
Abstract：Objective To investigate the diagnostic value of serum levels of cortisol ( Cor ) and neuropeptide Y ( NPY) in predicting malignant cerebral infarction in patients with cerebral infarction .Methods The clinical data about 95 patients with hemisphere massive cerebral infarction were collected .According to clinical symptoms and brain CT findings ,the patients were divided into malignant middle cerebral artery infarction goup ( MMI group ) and non-MMI group.The serum levels of NPY and Cor were detected ,and receiver operating characteristic curve ( ROC) was used to evaluate the diagnostic value of serum levels of NPY and Cor in predicting occurrence of MMI .Results The proportions of fever,nausea,vomiting and irritability in MMI group were significantly higher than tose in non-MMI group ( P <0.05).The serum levels of NPY and Cor in MMI group were significantly higher than those in non-MMI group.ROC curve analysis showed that the area under curve for the serum levels of NPY in predicting the occurrence of MMI was 0.749 (95% CI:0.636~0.862), during the serum NPY=175.4ng/L,the sensitivity and specificity were 72.1%,73.5%, respectively, and for the serum levels of Cor , the area under curve was 0.851 (95%CI:0.754~0.948),during the serum Cor=40.5μg/L,the sensitivity and specificity were 86.9%,82.4%,respectively,however, during combining the two factors ,the area under curve was 0.926 (95% CI:0.870~0.983), sensitivity and specificity were 93.4%,79.4%,respectively.Conclusion The serum levels of NPY and Cor in patients with MMI are increased ,and combination detection of two factors is helpful to the early diagnosis of MMI .
Keywords：malignant cerebral infarctionneuropeptide Ycortisolprediction
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 534-536 )