Application value of cervix thinprep cytological test combined with vaginoscopy in screening of precancerous lesions of cervical cancer

doi:10.3969/j.issn.1002-7386.2017.04.011

Abstract：Objective To investigate the diagnostic value of thinprep cytological test ( TCT ) combined with vaginoscopy in screening of precancerous lesions of cervical cancer .Methods Five hundred and sixty-three female patients underwent screening for cervical cancer by means of TCT or vaginoscopy .Taking the pathological examination results as gold standard,the correlation between the results by TCT or vaginoscopy and those by histopathologic examination was analyzed , moreover , the clinical application value of single TCT detection , single vaginoscopy or combination detection by two methods was evaluated.Results Among 563 woman patients,there were 178 positive cases of TCT detection and (or) vaginoscopy in whom there were 34 normal or cervicitis patients according to pathological examination results , 54 cases of CINⅠstage,49 cases of CIN II stage,37 cases of CIN Ⅲstage,4 cases of invasive carcinoma ,and the consistency coefficient of TCT and pathology for cervical cancer screening was 0.755, which of vaginoscopy and pathology for cervical cancer screening was 0.500.The accuracy of TCT combined with vaginoscopy in diagnosis of cervical cancer was higher than that of TCT or vaginoscopy alone,moreover,which by TCT was higher than that by vaginoscopy .The area under ROC curve in diagnosis of cervical cancer by TCT, vaginoscopy and combination detection of two methods was 0.840,0.705, 0.890, respectively. Conclusion The detection of TCT or vaginoscopy is helpful to the diagnosis of precancerous lesions of cervical cancer , moreover , the combination detection of TCT with vaginoscopy has higher diagnostic value .