The application value of single CA125 detection and combination detection of multi-item tumor indexes in diagnosis of ovarian cancer

XIANG Tian; LIU Gao

doi:10.3969/j.issn.1002-7386.2017.04.010

Abstract：Objective To investigate the value of single CA 125 detection and combination detection of multi-item tumor indexes in diagnosis of ovarian cancer .Methods One hundred and thirty-six patients with ovarian tumor who were admitted and treated in department of gynecology of our hospital from April 2014 to April 2016 were enrolled in the study . According to surgical pathological results ,these patients were divided into ovarian cancer group (group A, n =78) and ovarian benign tumor group ( group B, n =58 ). The serum levels of CA125, CA153, CA199, CEA were detected by chemiluminescence particles immunoassay, in accordance with international reference standards:CA125 >35kU/L,CA153>30kU/L,CA199>37kU/L,CEA >5μg/L being regarded as positive diagnostic criteria .Results The serum levels of CA125,CA153,CA199,CEA in group A were significantly higher than those in group B ,moreover, the positive rates of CA125 in group A were significantly higher than those of CA 153,CA199,CEA ( P <0.05).The sensitivity,specificity,positive predictive value,negative predictive value,accuracy of single CA125 detection were 76.92% (60/78),81.03% (47/58), 84.51% (60/71), 72.31% (47/65), 78.68% (107/136),respectively,However,the sensitivity and accuracy by combination detection of CA125+CA153+CA199 were significantly higher than those by single CA 125 detection,moreover the specificity ,positive predictive value ,negative predictive value were significantly higher than those by combination detection of CA125+CA153+CEA, CA125+CA199+CEA, CA125+CA153+CA199+CEA ( P <0.05).The positive rates of CA125,CA153,CA199, CEA in stage Ⅲ ~Ⅳovarian cancer were significantly higher than those in stage Ⅰ ~Ⅱovarian cancer,moreovee, there were significant differences in different FIGO stages ( P <0.05).Conclusion The combination detection of CA125+CA153+CA199 plays an important role in diagnosis of ovarian cancer ,which can be used as evaluation indexes in FIGO staging of ovarian cancer .