Effects of angiotensin converting enzyme inhibitors on cerebral vascular reactivity in patients with hypertension complicated by lacunar cerebral infarction
REN Huiling
LIU Junyan
Abstract：Objective To observe the effects of angiotensin converting enzyme inhibitors on cerebral vascular reactivity ( CVR ) in patients with hypertension complicated by lacunar cerebral infarction , and to explore its action mechanism.Methods Thirty-one patients with lacunar cerebral infarction were enrolled as observation group in the study , moreover , the other 31 patients with hypertension ( the same age and sex as those in observation group ) were served as control group.All the subjects were treated by benazepril for three months ,and the CVR of patients was detected by routine TCD and breath-holding test before and after treatment .Moreover the correlation between breath-holding index ( BHI) improvement and blood presure decrease was evaluated by means of Pearson product-moment analysis .Results There was no correlation between BHI improvement and blood presure decrease in both groups ( P <0.05),which suggested that the effects of ACEI drugs on brain haemodynamics were independent of antihypertensive effects , moreover, ACEI drugs had neuroprotection effects.Conclusion ACEI drugs can improve cerebral vascular regulation ability in patients with lacunar cerebral infarction , moreover , the action is not related with its antihypertensive effects .
Keywords：cerebral vascular reactivityangiotensin converting enzyme inhibitortranscranial Doppler sonographylacunar cerebral infarction
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 375-377 )