The predictive value of PCT,hs-CRP,TNF-αin elderly patients with multiple organ dysfunction syndrome caused by acute cerebral vascular disease
WANG Jun
LING Xin
ZHANG Dongxin
Abstract：Objective To investigate the predictive value of serum levels of procalcitonin (PCT) ,high sensitivity C reactive protein ( hsCRP) and tumor necrosis factor-α( TNF-α) in elderly patients with multiple organ dysfunction syndrome (MODS) caused by acute cerebral vascular disease (ACVD).Methods A total of 158 elderly patients with ACVD were divided into MODS group and non-MODS group.The serum levels of PCT and hsCRP in peripheral blood of patients were detected by immunofluorescence assay ,and the serum levels of TNF-α were detected by enzyme linked immunosorbent assay (ELISA) on 6 hours and 1,2,3,5,7d after attack of ACVD.Moreover the examination results were analyzed and compared with those of 70 healthy subjects ( control group ) .Results As compared with those in control group ,the serum levels of PCT , hsCRP and TNF-α were significantly increased in every time point in ACVD group ( P <0.01).As compared with those in non-MODS group,the serum levels of PCT ,hsCRP and TNF-α in ACVD group were significantly increased in every time point (P<0.01).The area under ROC curve of PCT,hsCRP and TNF-αwas 0.887,0.796,0.753,respectively.The sensitivity, specificity and accuracy of PCT for predicting MODS was 83.9%,85.5%,86.4%,respectively.Conclusion The serum levels of PCT,hsCRP and TNF-α are obviously increased in elderly patients with ACVD ,moreover,the increase extent is closely related with ACVD complicated by MODS .The sensitivity and specificity of PCT are superior to those of hsCRP and TNF-α,thus,which can be regarded as a better diagnosis index to evaluate patient 's condition and to assess therapeutic effects .
Keywords：procalcitoninsuper-sensitivity C reactive proteintumor necrosis factor-αmultiple organ dysfunction syndrome
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 325-327,331 )