The role of matrix metalloproteinases in the pathogenesis and development of cerebral hemorrhage and the influencing factors on prognosis of cerebral hemorrhage
YANG Hongqing
LUO Yang
Abstract：Objective To investigate the role of matrix metalloproteinases (MMP-2 and MMP-9) in the pathogenesis and development of cerebral hemorrhage ,and to analyze the influencing factors on prognosis of cerebral hemorrhage .Methods Fifty patients with cerebral hemorrhage were served as cerebral hemorrhage group ,and 50 healthy subjects were served as control group .The levels of MMP-2 and MMP-9 in different time points after disease attack were detected by ELISA , meanwhile, patient' s cerebral hematoma and cerebral edema volume were observed , and neurologic impairment status was evaluated according to NIHSS score,moreover,the possible influencing factors on patient 's prognosis were analyzed.Results As compared with those in control group , the levels of MMP-2 and MMP-9 in cerebral hemorrhage group were significantly increased on 1d,3d,7d,14d after cerebral hemorrhage ( P <0.05).The levels of MMP-9 on 7d,14d after cerebral hemorrhage were positively correlated to cerebral edema volume ( r =0.079, 0.220, respectively, P <0.05).Moreover the cerebral edema volume and surgery opportunity were closely correlated to short -term prognosis of patients ( P <0.05 ) , besides, surgery opportunity was closely related with long-term prognosis of patients ( P <0.05 ) .Conclusion The over-expression of MMP-9 is closely related with the formation of edema after cerebral hemorrhage ,and cerebral edema volume and surgery opportunity can be regarded as the indexes to predict the prognosis of patients with cerebral hemorrhage .
Keywords：cerebral hemorrhagematrix metalloproteinasesprognosis
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 211-213 )