Influences of intracoronary administration of tirofiban on the therapeutic effects of interventional therapy on acute ST segment elevation myocardial infarction

doi:10.3969/j.issn.1002-7386.2017.02.012

Abstract：Objective To investigate the influences of intracoronary administration of tirofiban on the therapeutic effects of interventional therapy on acute ST segment elevation myocardial infarction .Methods Seventy-three patients with acute ST segment elevation myocardial infarction were randomly divided into observation group and control group .The patients in observation group were given intravenously tirofiban 20μg/kg before operation , then given tirofiban at the speed of 0.225μg· kg-1 · min-1 by continuous intravenous infusion ,however,the patients in control group were given intravenously tirofiban 10μg/kg before operation,then given tirofiban at the speed of 0.150μg· kg-1 · min-1 by continuous intravenous infusion.The therapeutic effects were observed and compared between two groups .Results The proportion of patients with TIMI grade 3 was 87.50%in observation group ,which was significantly higher than that (69.70%) in control group ( P <0.05).After operation ,the LVEF in observation group was significantly higher than that in control group ( P <0.05). The incidence rate of complications in observation group was 15.00%(6/40),which was 9.09%(3/33) in control group,there was no significant difference between two groups ( P >0.05).The incidence rate of adverse cardiac events in observation group was 5.00% (2/40),which was significantly lower than that [27.27% (9/33)] in control group ( P <0.05). Conclusion The higher dose of tirofiban can effectively improve the myocardial blood flow perfusion in patients with acute ST segment elevation myocardial infarction and can obviously reduce the incidence rates of postoperative adverse events , thus, which has higher feasibility and practicality .