Effects of piribedil combined with escitalopram oxalate on motor function and cognitive function of patients with Parkinson
TU Hailing
CHEN Guoqiang
WANG Liping
Abstract：Objective To observe the effects of piribedil combined with escitalopram oxalate on motor function and cognitive function of patients with Parkinson .Methods One hundred and fifty-five patients with Parkinson were divided into two groups according to random number table: single medication group ( piribedil only ) and combination medication group ( piribedil+escitalopram oxalate ) , with 55 patients in each group .The therapeutic effects and motor function of patients were evaluated by UPDRS Part Ⅰ-Ⅳ,Hoehn-Yahr staging,and the cognitive function of patients was assessed by MMSE ,WMS, DPN,CDT,moreover, the adverse reactions during medication were observed and comapred between two groups .Results There were significant differences in the effective rates (83.6%vs 56.4%) and the proportion of Hoehn-Yahr stagingⅠ~Ⅱ(85.5%vs 69.1%) after treatment between two groups ( P <0.05).Meanwhile, there were significant differences in the total scores of UPDRS Ⅱ, UPDRS Ⅲ and UPDRS between two groups ( P <0.05 ).Besides, there were significant differences in WMS, DPN,CDT between two groups ( P <0.05).However there were no significant differences in the incidence rates of adverse reactions between two groups ( P >0.05).Conclusion The piribedil combined with escitalopram oxalate may improve the motor function of patients with Parkinson , moreover , which may improve the recovery of cognitive function.
Keywords：piribedilescitalopram oxalateParkinson
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 201-203,207 )