Expression and significance of serum omentin and adiponectin in patients with hepatitis C liver cirrhosis

doi:10.3969/j.issn.1002-7386.2017.02.009

Abstract：Objective To detect the serum levels of omentin and adiponectin in patients with hepatitis C liver cirrhosis,and to explore the correlation between their expressions and insulin ,Child-Pugh,liver biochemical indexes and blood lipids.Methods The serum levels of omentin ,adiponectin and clinical biochemical parameters in patients with hepatitis C liver cirrhosis were detected in 56 cases of hepatitis C liver cirrhosis (case group) including 17 cases of grade A,20 cases of grade B and 19 cases of grade C as well as in 32 healthy subjects .Results The serum levels of omentin and adiponectin in case group were significantly higher than those in control group ( P <0.05), however,there were no significant differences in the serum levels of omentin and adiponectin among grade A ,B,C in case group ( P >0.05) .The serum levels of omentin and adiponectin in case group were not correlated to those of HOMA-IR,insulin ( r =-0.07, -0.14, -0.10, -0.04, respectively, P >0.05),however,the the serum levels of omentin were positively correlated to those of adiponectin ( r =0.37, P <0.01).Conclusion The serum levels of omentin and adiponectin are increased in patients with hepatitis C liver cirrhosis,thus,which can be regarded as the indexes to predic hepatitis C liver cirrhosis ,however,which can not be used as the indexes to evaluate the severity of liver function of patients .