Effects of IL-18 on the expressions of CD80,CD86,MHCⅠ,MHCⅡ in tumor tissues of rats with glioma
CHENG Tianjun
SONG Yangying
Abstract：Objective To observe the effects of 9L/IL-18 on the expressions of CD80,CD86,MHCⅠand MHCⅡin tumour tissues of rats transfected with IL-18, and to explore the anti-tumour effects of IL-18.Methods The F344 rats were randomly divided into three groups ,with 7 rats in each group,and these rats were inoculated with 9L/IL-18 cells,9L/LXSN cells,9L cells,respectively.The expression levels of CD80,CD86,MHCⅠ,MHCⅡin tumor tissues were detected by flow cytometry.Results The expression levels of CD80,CD86,MHCⅠin tumor tissues of rats inoculated with 9L/IL-18 cells were significantly higher than those in tumor tissues of rats inoculated with 9L/LXSN cells and 9L cells ( P <0.05).However there were no significant differences in the expression levels of CD 80,CD86,MHCⅠbetween 9L/LXSN cell inoculation group and 9L cell inoculation group ( P >0.05).There were no significant differences in the expression levels of MHCⅡ among the three groups ( P >0 .05 ) .Conclusion IL-18 may promote the differentiation and maturation of dendritic cells by increasing the expressions of CD80, CD86, MHCⅠon the surface of tumor cells,thereby,which may activate T cells,enhance the antigent activity of tumour cells to improve the effects of immune surveillance and to produce anti -tumor effects .
Keywords：interleukin-18gliomaanti-tumor
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 40-42 )