Diagnostic and prognostic value of combination detection of high sensitivity C reactive protein, carbohydrate antigen 125 and HE4 in endometrial carcinoma

doi:10.3969/j.issn.1002-7386.2017.01.005

Abstract：Objective To investigate the diagnostic and prognostic value of combination detection of high sensitivity C reactive protein (hs-CRP),carbohydrate antigen 125 (CA125) and HE4 in endometrial carcinoma.Methods One hundred and twenty patients with benign or malignant endometrial lesions were enrolled in the study .According to the disease degree , these patients were divided into endometrial cancer group (trial group) and endometrial benign lesion group (control group), at the same time, 50 healthy women were served as control group .The levels of hs-CRP, CA125 and HE4 were detected before operation to evaluate the effectiveness and prognosis .Results As compared with those in control group , the serum levels of hs-CRP,CA125,HE4 in trial group were obviously increased ,moreover, with the aggravation of disease degree ,the serum levels of hs-CRP,CA125,HE4 were significantly increased ( P <0.05).The positive rate of hs-CRP was 55.83%in trial group,which was significantly higher than that in control group ( P <0.05).The detection positive rates of hs-CRP, CA125,HE4 in trial group were significantly higher than those in control group ( P <0.05).After operation there were no significant differences in the serum levels of hs-CRP,CA125,HE4 between trial group and control group ( P >0.05), moreover, there were no significant differences in detection positive rates of hs-CRP,CA125,HE4 between trial group and control group ( P >0.05).The ROC curve analysis combined with single detection or combination detection of hs -CRP, CA125,HE4, human epididymis protein 4 showed that the area under curve detected by combination detection of hs -CRP, CA125,human epididymis protein 4 was the largest (0.835),however, in single detection of HE4,the area under curve was the largest (0.806),which was greater than that of hs-CRP (0,683) and that of CA125 (0.670).The sensitivity and specificity of combined detection of three indexes in diagnosis of endometrial cancer were 64.7% and 98.1%,respectively, with Youden index being 0.65,which were superior to those of single detection .The diagnostic efficacy of single detection of human epididymis protein 4 was superior to that of hs-CRP and CA125,moreover, its diagnostic sensitivity and specificity as well as Youden index were significantly higher than those of hs-CRP and CA125 ( P <0.05).Conclusion The combination detection of hs-CRP,CA125,HE4 in diagnosis of endometrial carcinoma is superior to single detection ,with high sensitivity and good accuracy ,thus ,which is worth using widely in clinical practice .