The levels and significance of serum cytokines -IL-6, IL-10 and TNF-αin children patients with recurrent upper respiratory tract infection in 0 ~3 years age group

LI Chun; YE Mei

doi:10.3969/j.issn.1002-7386.2017.01.003

Abstract：Objective To observe the changes of serum levels of interleukin-6 ( IL-6 ) , interleukin-10 ( IL-10 ) and tumor necrosis factor-α( TNF-α) in children patients with recurrent upper respiratory tract infection ( rURTIs) in 0~3 years age group,and to explore its significance .Methods Ninety children patients with rURTIs in 0~3 years age group who were treated in our hospital from May 2013 to April 2014 were enrolled as observation group in which 30 cases in 0~1 year group, 30 cases in 1~2 years group and 30 cases in 2~3 years group,moreover, the other 90 healthy children were served as control group in which 30 cases in 0~1 year group, 30 cases in 1~2 years group and 30 cases in 2~3 years group.The serum levels of IL-6,IL-10,TNF-αwere detected and compared among the groups .Results The serum levels of IL-6 in observation group were significantly higher than those in control group ( P <0.01),however,there were no significant differences in the serum levels of IL-10 between 0~1 year group and 2~3 years group ( P >0.05).The serum levels of IL-10 in 1~2 years group and 0~3 years group of observation group were significantly lower than those in control group ( P <0.01, P <0.05). Moreover the serum levels of TNF-αin 0 ~1 year group, 1 ~2 years group, 2 ~3 years group of observation group were significantly higher than those in control group ( P <0.05 or P <0.01).Conclusion The serum levels of IL-6,IL-10 and TNF-αin children patients with rURTIs in 0 ~3 years age group are changed obviously , which suggests that cytokines are involved in the pathogenesis of rURTIs , and the decrease of cellular immune function of children plays an important role in the pathogenesis and development of rURTIs .