Expression and significance of MMP-3 and E-cadherin in human neuroglioma

HE Runzhi; GAO Wensheng

doi:10.3969/j.issn.1002-7386.2017.01.002

Abstract：Objective To investigate the expression and significance of MMP-3 and epithelium cadherin ( E-cadherin ) in human neuroglioma .Methods The expression levels of MMP-3 and E-cadherin were detected by immunohistochemistry in 50 cases of neuroglioma tissues and 10 cases of normal brain tissues .Results There were significant differences in the expression levels of MMP-3 and E-Cadherin between neuroglioma tissues and normal brain tissues ( P <0.01).In neuroglioma,the expression rates of MMP-3 positive cells were increased with the increase of tumor malignant extent,moreover, the expression levels of MMP-3 in highly malignant neuroglioma (grade Ⅰ~Ⅱ) were significantly higher than those in lowly malignant neuroglioma (gradeⅢ~Ⅳ) ( P <0.05).However the expression rates of E-cadherin positive cell were decreased with the increase of tumor malignant extent , moreover, the expression levels of E-cadherin in lowly malignant neuroglioma ( grade Ⅲ~Ⅳ) were significantly higher than those in highly malignant neuroglioma ( gradeⅠ~Ⅱ) ( P <0.05).Spearman rank correlation analysis showed that the expressions of MMP-3 were negatively correlated to those of E-cadherin ( r s=0.637, P <0.01).Conclusion The expressions of MMP-3 and E-cadherin are closely correlated to the invasion and metatasis of neuroglioma ,moreover , the two factors may have synergetic effects during invasion of neuroglioma .