Comparison of the therapeutic effects between ranibizumab intravitreal injection and triamcinolone acetonide on cystoid macular edema due to retinal vein occlusion
ZHENG Mingwei
Abstract：Objective To investigate the therapeutic effects and safety of ranibizumab intravitreal injection and triamcinolone acetonide on cystoid macular edema (CME) due to retinal vein occlusion (RVO).Methods Ninety-seven patients with CME due to RVO were divided into two groups according to different therapeutic methods , the 47 patients in ranibizumab group were treated with ranibizumab 0.5mg (0.05ml) by intravitreal injection,however,the 50 patients in triamcinolone acetonide group were treated with triamcinolone acetonide 4.0mg ( 0.1ml ) by intravitreal injection .After treatment, the patients were followed up for 6 months, the best corrected visual acuity ( BCVA),central macular thickness (CMT),intraocular pressure and incidence rates of complications were observed and compared between two groups .Results After treatment the BCVA in different time points was significantly increased in both groups , as compared with that before treatment ( P <0.05), however,there was no significant difference between two groups ( P <0.05).After treatment the CMT in different time points was significantly decreased in both groups ,as compared with that before treatment ( P <0.05), however,there was no significant difference between two groups ( P <0.05 ).There was no significant difference in intraocular pressure of ranibizumab group in different time points after treatment and before treatment ( P >0.05).However the intraocular pressure in triamcinolone acetonide group in different time points were significantly increased after treatment ,as compared with that before treatment and that in ranibizumab group ( P <0.05).Besides there were significant differences in the incidence rates of intraocular pressure increasing between two groups ( P <0.05).Conclusion The intravitreal injection with ranibizuma in treatment of cystoid macular edema due to retinal vein occlusion can effectively increase BCVA ,decrease CMT, its therapeutic effects are similar to those of triamcinolone acetonide , moreover, its safety is better than that of triamcinolone acetonide .
Keywords：ranibizumabtriamcinolone acetonideretinal vein obstructionmacular vesicular edema
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 3711-3713 )