Expression and significance of inflammatory biological markers in serum of patients with endometriosis
DENG Aihui
Abstract：Objective To investigate the the changes and significance of serum levels of inflammatory cytokines including TNF-α,IL-1β,IL-6,IL-8,CA-125,MMP-3,and VEGF in serum of patients with endometriosis (EMs),and to analyze the correlation between the changes and pathological changes of EMs ,γ-AFS clinical staging and dysmenorrhea degree of patients.Methods A total of 61 patients with endometriosis (observation group) and 36 healthy women (control group) were enrolled in the study.The serum levels of TNF-α,IL-1β,IL-6,IL-8,CA-125,MMP-3,and VEGF in both groups were detected by immunosorbent assay ( ELISA ) , and the differences between the two groups were analyzed .Moreover the differences of the serum levels of these factors in patients with EMs at different stages were observed before operation and after operation.The correlation between these factors and dysmenorrhea scores of patients were analyzed .Results The serum levels of TNF-α,IL-1β, IL-6, IL-8, CA-125 and VEGF in observation group were significantly higher than those in control group (P<0.05),moreover,which were increased with the aggravation of pathological changes of Ems and γ-AFS clinical staging, however, which were decreased rapidly after resection of ectopic endometrium .Moreover the serum levels of TNF-α,IL-1βand IL-6 of patients with severe dysmenorrhea were significantly higher than those of patients without dysmenorrhea ( P <0.05). The serm levels of TNF-a,IL-1βand IL-6 in patients with EMs were positively correlated to the severity of dysmenorrhea of patients.The serum levels of MMP-3 in serum of patients with EMs were significantly increased ( P <0.05).After resection of ectopic endometrium the serum levels of MMP-3 were decreased quickly , however , the serum levels of MMP-3 were not closely correlated to r-AFS clinical staging of patients with EMs ,moreover, which were not closely related with the severity of dysmenorrhea of patients .Conclusion The detection of serum levels of TNF-α,IL-1β,IL-6,IL-8,CA-125,MMP-3and VEGF has a certain value in the diagnosis of endometriosis , moreover , which can be regarded as noninvasive auxiliary examination method .
Keywords：endometriosisdysmenorrheainflammatory cytokinescarbohydrate antigen-125matrix metalloproteinase-3vascular endothelial growth factor
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 3685-3689,3694 )