Effects of laparoscopic cholecystectomy on immune function of patients with senile acute gangrenous cholecystitis
ZHOU Jian
GAO Chun
TANG Xuedian
Abstract：Objective To compare the therapeutic effects of laparoscopic cholecystectomy and open cholecystectomy on senile acute gangrenous cholecystitis ,and to observe their effects on immune function of patients .Methods One hundred and twenty elderly patients with acute gangrenous cholecystitis who were admitted and treated in our hospital from January 2012 to December 2015 were divided into observation group ( n =60 ) and control group ( n =60 ) according to random number table.The patients in control group were treated by open cholecystectomy , however, the patients in observation group were treated by laparoscopic cholecystectomy .After treatment the operation time , intraoperative hemorrhage volume , the time of passage of gas by anus , hospitalization time , visual analogue scales ( VAS) , gastrointestinal living quality index ( GLQ) and incidence rates of complications were observed and compared between two groups .Moreover the levels of interleukin (IL)-10, interferon (INF)-γ, IL-2, IL-4, CD3+, CD4+, CD8+,CD4+/CD8+were detected and compared between two groups before and after treatment.Results The operation time, intraoperative hemorrhage volume, time of passage of gas by anus, hospitalization time, VAS and incidence rates of complications in observation group were significantly shorter or lower than those in control group ( P <0.01), however, GLQ scores in observation group were superior to those in control group ( P <0.01).Before treatment there were no significant differences in the levels of IL-10, INF-γ, IL-2, IL-4, CD3+, CD4+, CD8+CD4+/CD8+between two groups ( P >0.05), however,after treatment the levels of IL-10,IL-4,CD3+,CD4+and CD4+/CD8+were significantly decreased in both groups , as compared with those before treatment ( P <0.01 ) .Moreover there were significant differences in the levels of IL-10, INF-γ, IL-2, IL-4, CD3+, CD4+, CD8+, CD4+/CD8+after treatment between two groups ( P <0.01 ).Conclusion The laparoscopic cholecystectomy has obvious therapeutic effects on senile acute gangrenous cholecystitis,which is superior to open cholecystectomy ,which plays an important role in controlling inflammation and alleviate immunological drift .
Keywords：acute gangrenous cholecystitisimmune functionlaparoscopycurative effects
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 3561-3563,3568 )